Granted it is Nature Protocols which started its publication run when I was in grad school and is likely less high-impact as full blown Nature. Seriously tough - using the Solver Add-in in Excel to do non-linear curve fitting gets published? If a younger version of myself knew about this, I'd have a Nature publication as a junior in undergrad.
It should be noted that such Nature worthy protocols are accomplished in the following 6 lines of R code (in this case for fitting a Michaelis-Menton curve):
f = formula(v ~ vmax*s/(km + s)) data = data.frame( s = c(1250, 625, 313, 156, 78, 39, 20, 10), v = c(148.68, 123.66, 96.84, 69.76, 45.54, 27.84, 16.38, 9.24) ) fit = nls(f, data=data, start=list(vmax=1, km=1), algorithm='port', trace=F, lower=0) summary(fit)
(note: I'm including the blank line in my 6-line count) On a similar thread, does that mean I can get a publication for this?